Centre of Excellence

Neuro-otology and Vestibular Laboratory

Neuro-otology is a subspeciality of ENT. The Neuro-Otology and Vestibular Lab was established in the Department of ENT, Head and Neck Surgery in November 2020. It is a dedicated centre for managing patients suffering from vertigo and other diseases causing disequilibrium. Vertigo and dizziness are common presenting symptoms for clinicians of all specialties. It has a lifetime prevalence of around 20–30%. The diagnosis of vestibular disorders has seen tremendous advancement with the advent of new technology and equipment. There are over 40 common inner ear disorders, including those of the central nervous system, which can lead to vertigo. The comprehensive management of these disorders includes a detailed history, appropriate investigations, rational treatment and rehabilitation strategies. The first step to successful treatment is establishing a diagnosis. Vertigo and dizziness are symptoms like headaches, nausea or fevers that relate to specific pathologic conditions. Hence, the interpretation of history with clinical and diagnostic tests is important. The Neuro-Otology Clinic will function on Tuesdays, Thursdays and Saturdays from 10 a.m. to 1 p.m. in the ENT Department, Ist floor of the SRM Hospital. It will be jointly managed by suitably qualified professionals from the departments of ENT, Audiology and Neurology. Patients are scheduled based on the prior appointment only. The contact person is the nurse in charge of ENT OPD and the contact number is +9144 47432386.

Vestibular Laboratory

In order to evaluate the vestibular system and enable the clinician to arrive at a precise diagnosis, tests and investigations are usually done in the newly created vestibular lab. These tests are

Dynamic Visual Acuity (DVA)

It is the best test to diagnose vestibulotoxicity and peripheral vestibulopathy, usually caused by ototoxic drugs. It can also be used as a rehabilitation tool and to assess the outcome of rehabilitation.

Computerized Stabilometry (Posturography)

Stabilometry helps in the functional evaluation of the postural control system in its steady-state behaviour. It measures the outcome of vestibular rehabilitation by assessing the patient’s balance control and postural sway velocity.

Rhythmic Weight Shift (RWS)

To quantify the patient’s ability to rhythmically move their COG from left to right and forward to backward between two targets at different speeds.

Subjective Visual Vertical (SVV)

It is used to evaluate the otolith system responsible for the perception of verticality. It helps to diagnose various otolithic disorders, chronic dizziness and compensated vestibular disorders, differentiate peripheral vestibular disorders from central vestibular disorders and assess the effect of rehabilitation in vertigo patients. To quantify the patient’s ability to rhythmically move their COG from left to right and forward to backward between two targets at different speeds.

Craniocorpography (CCG)

It is an objective investigation to evaluate the vestibulospinal reflex. Romberg’s test, Tandem’s walking test, and Unterburger/Fukuda’s test are done.

Videonystagmography (VNG)

It is a non-invasive, accurate and reliable way of evaluating the vestibular and oculomotor systems. It evaluates peripheral and central vestibular functions through spontaneous nystagmus with and without optic fixation, gaze-evoked nystagmus, saccades, optokinetic tests, caloric tests, head shaking tests, smooth tracking with various frequencies, positional tests, valsalva and hyperventilation-induced nystagmus and skew deviation.

Video Head Impulse Test (vHIT) with VOR Suppression Test

The vHIT enables the testing of all six semi-circular canals at high frequency, as well as the saccade strategies (overt and covert). The important features are
  • Quick test: In 10 minutes, all six semi-circular canals can be tested.
  • Nine-axis motion sensors accurately measure head movement, allowing for simultaneous comparison of head and eye movements.
  • Monocular high-frame rate camera with 200 fps to detect fast eye movements
  • Lightweight goggle design to reduce slippage.
  • Built-in lasers that provide stimulus for calibration and VOR testing.
  • Fully integrated and computerised, with real-time recording of all parameters
  • Videos of the eye movements can be viewed after the test.

Vestibular Rehabilitation Therapy (VRT)

VRT is used for treating vestibular disorders. The Cawthorne-Cookesy exercises, which are now over 60 years old, do not meet the requirement of vestibular compensation in many patients. It is important to identify the areas of dysfunction in order to tailor rehabilitation strategies. Rehabilitation needs to be progressive and adapt to the needs of the patient. It cannot be a “one size fits all” approach. Virtual reality-based rehabilitation is making rehab more real and able to expose the patient to real-life situations in the protected environment of the vestibular rehab clinic. Vertigo is a common multisensory syndrome. A thorough diagnostic assessment helps to establish the pathophysiology of the disorder. In recent times, the diagnosis of vertigo has undergone a paradigm shift due to new diagnostic possibilities. The introduction of modern vestibular test procedures in clinical practice has led to the assessment of all components of the vestibular organ. Combined with established methods, a frequency-specific assessment of the function of vestibular reflexes is possible. These developments have enabled the clinician to manage vertigo better through quicker evaluation with this diagnostic equipment and customise the rehabilitation therapy. The vestibular lab will function on all working days, from 10 a.m. to 1 p.m. It is located in the Department of ENT, Ist Floor, Hospital ‘B’ Block. Appointments are made with the nurse in charge of ENT OPD or by telephone at +914447432386.

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Mission

  • We commit to providing our pharmaceutical, biotechnology, nutrition and government sponsors with quality data and accurate execution of all protocol requirements in line with regulatory authorities.
  • We commit to educating our communities on medical research advances and the clinical trial process.
  • We provide our study participants with autonomy, respect and the utmost care and ethical integrity as per the ICH GCP.
  • We commit our team members to maintaining a friendly, fair, and creative work environment that respects diversity, new ideas, and hard work.

Vision

  • To develop scientific evidence through innovations related to diagnostic, preventive, promotive and therapeutic areas.
  • Our vision is a healthy and informed society with a strong quality of life due to the advancements of therapies in medicine, nutrition and devices.

Our Esteemed Clients:

Pharmaceutical Industries
  • Sanofi
  • GSK
  • Bharat Biotech International Limited
  • Serum Institutes of India
  • Shantha Biotechnics
  • PHRI-Canada
  • George Clinicals
  • IQVIA
  • ICON
  • Diagnosearch
  • LabCorp
  • Cliantha Research
  • Wockhardt
  • Veeda clinical research
  • Hetero Pharma
  • Glenmark
  • Gennova
  • Zydus Cadila
  • Alvogrn
  • Deva Holding
  • DNDi

Funded Government Agencies:

  • ICMR
  • BIRAC, DBT

Facilities Available:

  • State-of-the-art Infrastructure
  • Central Lab- SRM Hospital
  • NABL-accredited virology lab
  • Sample storage room with deep freezers (-80 ºC & -20 ºC)
  • NABH-approved facility at SRM Hospital
  • Data Storage: Highly Secured Access
  • High-speed network facilities
  • Power Backup: 24*7 hrs
  • Dedicated trial staff: 24*7 hrs
  • GCP-trained clinical research professionals
  • Pharmacy with 24-hour power backup and access control
  • ICU & MICU Facilities at SRM Hospital

Faculties and Staffs Name List

Sl.no Name of the Faculty and Staff Designation
1 Dr. Satyajit Mohapatra Director
2 Dr. Preethika A Assistant Professor
3 Mrs. Tharunya P Senior Clinical Research Associate
4 Ms. Keerthi Ragavan P Clinical Research Associate
5 Ms. Mohana Priya S Research Associate & Quality Assurance
6 Mr. Mohanraj P Clinical Research Coordinator
7 Mrs. Kamatchi M Research Nurse
8 Mrs. Anusuya S Research Nurse
9 Ms. Lavanya A Pharmacist
10 Mr. Sivakumar V Lab Technician
11 Mr. Arunselvam R Computer Operator
12 Mr. Ranjithkumar S Office Assistant

SRM Centre for Clinical Trials & Research @ SRM Hospital

Sl no Type of Clinical Trials (Drug/vaccine) Indication Candidate Sponsored / Academic Phase of Trial Year Status
1 Vaccine Rotavirus ROTAVAC Bharat Biotech Ltd. IV 2014-15 Completed
2 Vaccine Pentavalent vaccine SHAN5 Shanta Biotech, Hyderabad III 2015-16 Completed
3 Vaccine Rotavirus ROTA5C Bharat Biotech Ltd. III 2015-17 Completed
4 Monoclonal Antibody Acute Coronary Syndrome Alirocumab ODYSSEY OUTCOMES trial, Sanofi III 2015-19 Completed
5 Polycap formulation Primary prevention of CVD Aspirin-Vit D TIPS-3 study, PHRI, Canada III 2015-20 Completed
6 Vaccine Rotavirus ROTA5CM Bharat Biotech Ltd. III 2017-18 Completed
7 Vaccine Quadrivalent vaccine DTwP-Hib Bharat Biotech Ltd. III 2017-18 Completed
8 Drug Surgical Wound Lysostaphin Gel Bharat Biotech Ltd. IIb/III 2017-18 Completed
9 Vaccine Pentavalent vaccine DTwP-HepB-PRP-T Shanta Biotechnics III 2018-21 Completed
10 Drug Asthma Salbutamol Cliantha Research BA/BE 2019-20 Completed
11 Vaccine Meningococcal vaccine MET55 Sanofi III 2019-21 ongoing
12 Vaccine COVID rBCG SII, Pune II 2020-21 Completed
13 Vaccine COVID BBV152, Inactivated SARS-Cov-2 Vaccine Bharat Biotech Ltd. I 2020-21 Completed
14 Vaccine COVID BBV152, Inactivated SARS-Cov-2 Vaccine Bharat Biotech Ltd. II 2020-21 Completed
15 Vaccine COVID BBV152, Inactivated SARS-Cov-2 Vaccine bharat Biotech Ltd./ICMR III 2020-22 Completed
16 Vaccine Meningococcal vaccine MEQ00064 Sanofi III 2021 Proposed
17 Drug COVID Aspirin-Colchicine PHRI, Canada III 2021 ongoing
18 Vaccine COVID BBV152, Inactivated SARS-Cov-2 Vaccine Booster Dose Bharat Biotech Ltd III 2021-22 Completed
19 Vaccine COVID VAT00008/Monovalent/bivalent COVID vaccine Sanofi-GSK III 2021-22 ongoing
20 Drug Myocardial Infarction with Persistent ST Elevation HCR/III/TENESTEMI/08/2020 Hetero Biopharma Ltd III 2022 ongoing
21 Drug Osteo Arthritis HCR/III/POLMOA/21-22 Hetero Biopharma Ltd III 2022 ongoing
22 Monoclonal Antibody BONE METASTASES Denosumab Hetero Biopharma Ltd I/III 2022 ongoing
23 Drug BRONCHIAL ASTHMA Fluticasone Propionate Glenmark Pharmaceuticals Ltd. BE 2022 ongoing

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Contact Details:

Centre for Clinical Trials and Research 3rd Floor, E-Block Extension, SRM Medical College Hospital and Research Centre Kattankulathur-603203 Email: srmcctr@srmist.edu.in, Director.cctr@srmist.edu.in Contact Numbers: 7358026002

Comprehensive Cleft Care Program – SMILE TRAIN Project

A dedicated facility for the comprehensive management of children born with cleft lip and palate has been initiated in the Department of Plastic and Reconstructive Surgery at SRM Medical College Hospital and Research Centre, Kattankulathur. The cleft care is carried out by a multidisciplinary team comprising Cleft Reconstructive Surgeons, Plastic Surgeons, Oral and Maxillofacial Surgeons, Anaesthesiologists, Peadiatricians, ENT Surgeons, Orthodontists, Speech Language Pathologists and Audiologists, Clinical Psychologists, Community Medicine Specialists, Nutritionists, Nursing staff and other support services such as the Department of Radiology, Blood Bank, etc. In pursuit of excellence, the cleft care program of SRM Medical College Hospital and Research Centre, Kattankulathur, has partnered with ‘Smile Train’ with effect from February 1, 2022, onwards. Smile Train is an international organisation devoted exclusively to the noble cause of helping provide free treatment for any child born with a cleft lip and palate through credentialed hospitals worldwide. This partnership helps in establishing the cleft care program in our institution as the “SRM Centre of Excellence for Cleft Lip and Palate” for the provision of safe and quality care delivered on par with international standards. We have successfully provided free cleft lip and palate treatment to 70 underprivileged cleft lip and palate-born children. The most common deformity of the face is a cleft lip and/or cleft palate on one or both sides. This congenital deformity happens during the 8th to 12th weeks of fetal development. The possibility of early diagnosis and treatment planning starts with prenatal diagnosis by radiologists, obstetricians, and gynaecologists and postnatal first consultations for evaluation and counselling with paediatricians and cleft reconstructive surgeons. In a cleft team, feeding issues can be easily addressed by qualified nurses and nutritionists who train the mother and family members to use specialized feeding bottles and demonstrate correct feeding postures and techniques to provide necessary nourishment. A healthy cleft lip or palate child with adequate weight and height is often ready to undergo a surgical reconstructive procedure for a cleft lip as early as 3 months and 9 months for a cleft palate. In addition to the correction of the cleft, issues related to speech, hearing, dentition, facial growth, etc. will have to be dealt with by a child with a cleft during their growth and development. Later secondary reconstructive surgery, including Alveolar Bone Grafting (ABG), Rhinoplasty, jaw corrective surgery, etc., may be required at different ages from adolescence through adulthood. In addition to the correction of the cleft, issues related to speech, hearing, dentition, facial growth, etc. will have to be dealt with in a child with a cleft during their growth and development. The need for long-term, multidisciplinary intervention has driven us to establish a comprehensive cleft care program with the opportunity to evolve as a Centre of Excellence. The ultimate objective is “to provide all the required care for a child born with a cleft lip palate and craniofacial deformity addressed under a single roof by specialised professionals, enabling smiles across faces.”

Molecular Diagnostic Center

SRM Medical College Hospital and Research Centre has a state-of-the-art Biosafety Level 3 NABL-accredited Molecular Diagnostic Centre, which was inaugurated in September 2020. COVID (SARS CoV2) real-time PCR, Qualitative assay and Hepatitis C RT PCR are performed in the laboratory. A total of 11,358 samples were processed from January 2021 to June 30th, 2021, for effective management of the COVID-19 second wave. 46 samples for HCV RNA RT PCR were processed in the first six months of the calendar year 2021. We have been selected as one of the sites for the COVAXIN clinical trial, which is currently in Phase 3. We have processed 2100 samples as of June 30th, 2021, as part of this trial. The laboratory is currently in collaboration with WHO on two study projects. Study 1 is aimed at evaluating the seroprevalence of COVID-19 total Ig antibodies among healthcare workers in India. Study 2 is aimed at analysing the effectiveness of COVAXIN and COVISHIELD vaccines against severe COVID-19. It is a multicentric hospital-based case-control study. We have recruited 87 cases and 243 control subjects as of June 30th, 2021, for the study.